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In the U.S., routine vaccination against human papillomavirus (HPV) was recommended for girls in 2006 and for boys in 2009. Vaccinating girls prevents cervical cancer, and vaccinating boys adds protection to women through herd immunity. Vaccinating boys also protects against male cancers, particularly in men who have sex with men. However, vaccine uptake has been modest for girls and poor for boys (57% and 35%, respectively, have received at least one dose).
To estimate the cancer prevention benefit to men from vaccinating girls and boys, researchers used data from the Dutch national cancer registry on loss of quality-adjusted life years due to HPV-implicated cancers (penile, oropharyngeal squamous cell, and anal). The model predicted that a…