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Statins lower risk for adverse cardiovascular (CV) events in patients without known CV disease (Cochrane Database Syst Rev 2013; 1:CD004816). However, most trials of lipid-lowering drugs for primary prevention of CV disease have excluded older patients (age, ≥70). In this prospective cohort study, researchers in France determined the association between lipid-lowering-drug use and risk for coronary heart disease and stroke in 7500 elders (mean age, 74) without known CV disease. Of the 27% of participants who received lipid-lowering drugs at baseline, half used statins, and half used fibrates.
During mean follow-up of 9 years, 440 first coronary events and 292 first strokes occurred. In analyses that were adjusted substantially for numerous p…