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The increased use of antipsychotic drugs by pregnant women during the last decade is largely due to the overall greater use of more tolerable atypical antipsychotics in bipolar disorder and major depression.
To address the limited information about the effects of this new class of agents on both mother and fetus, investigators in Canada conducted a population-based cohort study that evaluated outcomes of 1021 mothers who delivered a single infant between 2003 and 2012 and filled at least one of ≥2 antipsychotic prescriptions (90% atypical) in the first or second trimester. These outcomes were compared with those of a propensity-matched sample of mothers from the general population who delivered during the same period but did not use antipsyc…