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Mycoplasma genitalium is a sexually transmitted bacterium that can cause urethritis, cervicitis, and pelvic inflammatory disease. Standard treatment for M. genitalium infections has so far been the macrolide antibiotic azithromycin. But is this recommendation still reasonable, given the increasing macrolide resistance among sexually transmitted pathogens?
To investigate this issue, researchers performed genotypic resistance testing on urogenital samples from a single diagnostic laboratory in the Netherlands. Of 421 samples from 378 patients that were positive for M. genitalium on routine polymerase chain reaction (PCR) testing between February 2012 and November 2014, 153 samples from 146 patients (55 males and 91 females) were positive for t…