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The common vaginal infections (vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis) tend to recur, but optimal regimens for suppression have yet to be determined. Researchers enrolled 234 women from one U.S. clinic and three African clinics in a 1-year, placebo-controlled trial of an intravaginal suppository (750-mg metronidazole plus 200-mg miconazole) used for 5 consecutive nights monthly. At study entry, all participants had ≥1 of the common vaginal infections, but none reported >3 such infections during the previous year, and none were HIV-positive. During follow-up, smears were collected every 2 months, and symptomatic recurrences were treated.
At 1 year, the women who received active drugs were about 35% less likely to ha…