Harnessing Molecular Biology to Evaluate Recurrent Pregnancy Loss

Single-nucleotide polymorphism microarray analysis could be valuable when assessing women with RPL.

Diagnosis and management of recurrent pregnancy loss (RPL; ≥2 consecutive losses before 13 weeks' gestation) is difficult, with no recognized cause usually identified. Now, a retrospective cohort study involving 42 women with RPL indicates that single-nucleotide polymorphism (SNP) microarray analysis using paraffin-embedded products of conception might yield valuable information.

Fetal chromosome number was successfully diagnosed with SNP microarray in 44 samples from 62 losses; of these, 19 were euploid (normal number of chromosomes) and 25 were noneuploid. The most common chromosomal abnormalities were trisomy 15 and monosomy X. Compared with women who had noneuploid products of conception, those with euploid losses were significantly more…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Harnessing Molecular Biology to Evaluate Recurrent Pregnancy Loss

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Reviewing Author