Stem Cells and Wounds

Stem cells can both self-renew and differentiate. Bone-marrow-derived mesenchymal stem cells (BM-MSCs) and adipose-derived stromal cells (ASCs) are particularly relevant to wound healing. They have potential for multilineage differentiation and share similar morphology, telomerase activity, gene expression, and cell surface marker phenotypes.

These authors reviewed the literature on evidence suggesting that MSCs accelerate wound healing. Most studies were in rodents; cell isolation techniques and delivery methods differed. Local applications with syringe-spray systems worked on a scaffold mimicking extracellular matrix. The local environment (soluble signaling molecules, neighboring cells, extracellular matrix, oxygen tension, among other fa…