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Data on the relation between glucocorticoids and peptic ulcer bleeding (PUB) are mixed, with some studies suggesting an increased risk for PUB and others showing no additional risk. To explore this issue, investigators in Taiwan searched a national database for adults hospitalized with newly diagnosed PUB between 2000 and 2012. They identified patients with short-term (≤28 days) antecedent use of glucocorticoids, using a case-crossover design to manage unidentified confounding factors and determine the self-matched odds ratios for PUB in patients with 7-day, 14-day, or 28-day exposure to glucocorticoids immediately preceding PUB diagnosis.
For the 8894 patients with PUB, the self-matched odds ratios for glucocorticoid exposure were 1.37 (95%…