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Investigators prospectively determined the prevalence and risk factors of clinically relevant intracranial abnormalities among children aged 29 days to 18 years presenting with an unprovoked seizure to one of six U.S. emergency departments (EDs) between 2005 and 2007. Patients were excluded if they had syncope, breath-holding episodes, altered mental status without seizure, known neurologic disorders, absence seizures, head trauma or fever in the previous 24 hours, toxin ingestion, or known metabolic disorder.
Of 444 patients (median age, 6 years), 354 (80%) received computed tomography or magnetic resonance imaging in the ED or within 4 months of the visit. Forty patients (11%) had clinically relevant intracranial abnormalities; the most co…