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Medical reasons for infants to avoid lactose are very rare, but parents often blame cow's-milk formula or the lactose it contains for their babies' feeding problems, fussiness, and other subjective symptoms. As a result, parents and also clinicians change formulas in an effort to treat these problems.
In an industry-supported, double-blind study, 300 babies (mean age, 5 weeks) fed with cow's-milk formula who presented with parent-reported fussiness/crying/cramping, gas, or diarrhea at one of 19 general pediatric clinics were randomized to receive lactose-free cow's-milk formula, soy-based formula, or regular lactose-containing cow's-milk formula.
After 2 weeks, no significant differences were observed between the three groups with respect to …