Estimating the Proportion of Undiagnosed HIV Cases

Using novel methodology, researchers estimated that in King County/Seattle, Washington, 6% of HIV infections in men who have sex with men are undiagnosed, with wide variation by race/ethnicity.

The first step in the HIV care cascade is determining the proportion of HIV infections that remain undiagnosed within a given jurisdiction. This task is difficult and often requires either testing a representative sample of high-risk individuals or obtaining an indirect measure by back-calculation to estimate HIV incidence. Now, researchers have used two new methods to estimate the undiagnosed fraction among men who have sex with men (MSM) in King County, Washington.

The first method, a back-calculation approach, requires no assumptions about HIV-incidence trends; the second is a simple formula used when HIV incidence is stable. Both methods use data on HIV testing history for newly diagnosed cases to estimate the time of last negative test,…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Estimating the Proportion of Undiagnosed HIV Cases

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Reviewing Author