Ebola Vaccine Highly Efficacious in a Ring Vaccination Trial

A single dose of a live candidate Ebola vaccine prevented all infections among contacts ≥6 days after vaccination

Several candidate Ebola vaccines have been developed. One — a recombinant, vesicular stomatitis virus–based preparation expressing the glycoprotein of a Zaire Ebolavirus (rVSV-ZEBOV; NEJM JW Infect Dis May 2015 and N Engl J Med 2015 Apr 1; [e-pub]) — causes transient systemic infection and induces rapid immune response against Ebola virus surface protein.

In an open-label, cluster-randomized, ring vaccination trial in Guinea in 2015, investigators administered a single intramuscular injection of rVSV-ZEBOV to the contact networks of patients with confirmed Ebola virus disease (EVD) immediately after the identified exposure or 21 days later. Nonpregnant adults with contact during the preceding 21 days were eligible. The number of individuals …

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Ebola Vaccine Highly Efficacious in a Ring Vaccination Trial

Topics

Reviewing Author