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Immune-mediated thrombocytopenia in newborns can result from the placental transfer of autoantibodies, generally of the immunoglobulin-G type, from mothers with primary immune thrombocytopenia (ITP). The condition usually persists in infants for less than 2 months.
To determine why some neonates have persistent thrombocytopenia, investigators examined the breast milk from seven women with ITP for the presence of antibodies directed against platelet antigens; these women were thrombocytopenic at the time of delivery. The researchers also studied the breast milk from nine healthy controls and from six women with ITP who were in remission and had normal platelet counts on the day of delivery.
Milk samples from four of the seven women with active…