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Although effectiveness of measurement-based care for major depression was demonstrated in STAR*D and other major studies, clinicians in practice have been slow to adopt this approach, perhaps partly because formal measurement has not been conclusively shown to be more effective than treatment as usual. In a government-funded study, investigators in China randomized 120 patients with major depression to 24 weeks of measurement-based or standard care. Patients averaged 3.2 prior episodes and 11 years of illness (mean age, 41; women, 64%; married, 78%).
Participants completed the 16-item Quick Inventory of Depressive Symptomatology (QIDS) and adverse event measures at each visit. Both measurement-based and standard arms limited clinicians to op…