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A 2006 study showed that adding intraperitoneal (IP) chemotherapy to intravenous (IV) chemotherapy following surgery significantly improves survival in women with stage III ovarian cancer (N Engl J Med 2006; 354:34), prompting the National Cancer Institute to urge the adoption of this approach. However, given barriers to the acceptance of combination IP/ IV chemotherapy — such as perceived toxicities, the potential for inpatient administration, and the lack of a standard regimen — how widely it has since been used in clinical practice is unclear.
Now, investigators have conducted a prospective cohort study to evaluate the use and effectiveness of IP/IV chemotherapy versus IV chemotherapy alone in 498 patients with optimally resected stage II…