Colorectal Cancer Risk in Serrated Polyposis

The absolute level of excess risk for colorectal cancer in patients with serrated polyposis syndrome (SPS) has been estimated at as high as 6% to 7% over 5 years but remains uncertain.

Investigators in Spain retrospectively assessed risk for colorectal cancer in 296 patients with SPS followed for a median duration of 45 months. Twenty-seven percent met WHO criteria for SPS of 5 or more serrated polyps proximal to the sigmoid with at least two polyps >10 mm in size, 45% met WHO criteria of at least 20 serrated lesions “throughout” the colon, and 28% fulfilled both criteria.

Mean patient age was 57 years, 70% had a body-mass index ≥25 kg/m², 75% were current or former smokers, 29% had a first-degree relative with colorectal cancer, and 4% had a…