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As antibiotic resistance of Helicobacter pylori increases, eradication rates with standard therapy decrease. Among the many alternative therapies that have been studied, which are the most effective?
To explore this question, researchers in China performed a systematic review and network meta-analysis. Their study, which involved 143 randomized, controlled trials selected from among 15,565 identified in the literature, covered 14 types of treatment for H. pylori infection.
Standard triple therapy (a proton-pump inhibitor [PPI] with clarithromycin plus either amoxicillin or metronidazole) for 7 days had the lowest eradication rates (73%; 95% confidence interval, 0.71%–0.75%). The highest rates were achieved with 10 or 14 days of concomitant tr…