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Both chronic cannabis use and schizophrenia have similar findings on magnetic resonance imaging of the dorsolateral prefrontal cortex in males (NEJM JW Psychiatry Jul 2007 and Biol Psychiatry 2007; 61:1281). To learn more, investigators examined the interrelationships among adolescent cannabis use, cortical thickness, and a polygenic schizophrenia risk score (based on 108 loci identified by the Psychiatric Genetics Consortium) in three independent samples (N=1087).
In two samples, only male participants who reported ever using cannabis showed lower mean cortical thickness, which was mediated by high polygenic scores. In the third sample, cortical thickness was lower in males with frequent cannabis use (frequency, ≥61 times) than in males who…