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Lipshütz disease (LD), also known as ulcus vulvae acutum, Epstein-Barr virus (EBV) vulvitis, or reactive nonsexually related acute genital ulcers, typically presents as multiple self-limited, punched-out, and painful ulcers on the labia minora of young, nonsexually active females. These ulcers are commonly associated with EBV, but also with cytomegalovirus (CMV), influenza, mumps, toxoplasmosis, mycoplasma, and salmonella. These authors explored histology in a retrospective review of seven women (median age, 27) with acute vulvar ulcerations during a serologically confirmed episode of active EBV infection.
More than half presented with two or more bilateral ulcers; one patient had five. Mean diameter and duration of the ulcers were 1 cm and …