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With substantial numbers of childbearing women now receiving atypical antipsychotic medications (AAs), patients and clinicians are concerned about their possible teratogenic effects. These investigators analyze data from a national registry focusing on effects of these medications during pregnancy.
There were 214 women with live births and first-trimester exposure to an AA (polypharmacy, 79%) and 89 controls with live births and no AA exposure during pregnancy (most with psychiatric histories and exposure to another type of psychotropic during pregnancy (polypharmacy, 44%). Of those exposed to first-trimester AAs, three (1.4%) delivered babies with a major congenital malformation: one had transposition of the great arteries, with exposure to…