Can Genomic Biomarkers Help Diagnose Severe CAP?

The FAIM3:PLAC8 gene-expression ratio had a positive predictive value of 83.1% and a negative predictive value of 81.3% for diagnosing CAP in intensive care unit patients.

Community-acquired pneumonia (CAP) can be difficult to diagnose clinically, leading to both overuse and misuse of antibiotic therapy. However, genome-wide transcriptional profiling of blood leukocytes might be able to differentiate infectious from noninfectious causes of disease.

To test this hypothesis, investigators conducted a study at two tertiary care centers in the Netherlands. A total of 234 patients admitted to the intensive care unit (ICU) with suspected CAP were divided by admission date into discovery and validation cohorts. Enrollees were classified as CAP patients or controls (no CAP) by post hoc analysis. Blood samples collected within 24 hours of admission were used for analysis.

Overall, blood leukocyte gene expression profile…

Reviewing Author

Neil M. Ampel, MD

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Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Can Genomic Biomarkers Help Diagnose Severe CAP?

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Reviewing Author