Antibiotic Susceptibility of Neisseria gonorrhoeae

Although national surveillance data suggest that the rise in cephalosporin resistance in N. gonorrhoeae has peaked, the improvements in susceptibility may be short-lived.

Increasing antibiotic resistance in Neisseria gonorrhoeae has led to CDC surveillance for resistance in this pathogen. The finding of decreasing cephalosporin susceptibility caused the CDC in 2010 to recommend combination therapy with either cefixime or high-dose ceftriaxone plus a second antimicrobial agent, and in 2012 to suggest ceftriaxone plus a second antimicrobial agent as the only recommended treatment. Based on data from the Gonococcal Isolate Surveillance Project (GISP), the CDC has now updated its information on gonococcal cephalosporin susceptibility.

Between 2006 and 2014, participating centers in 34 U.S. cities tested 51,144 gonococcal isolates. During this period, the proportion of patients treated with intramuscular ceftriaxo…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Antibiotic Susceptibility of Neisseria gonorrhoeae

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Reviewing Author