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Neonatal adaptation syndrome (characterized by tremors, irritability, and respiratory distress) has been reported in up to 30% of newborns prenatally exposed to selective serotonin reuptake inhibitors (SSRIs). In a prospective cohort study involving 184 women (mean age, 28) and their healthy, singleton infants born at ≥37 weeks' gestation, investigators examined neurobehavioral development during the first postnatal month after in utero exposure to SSRIs (52 pregnancies), SSRIs plus benzodiazepines (10 pregnancies), untreated unipolar depression (56 pregnancies), or no psychiatric disorder (66 pregnancies). Infants were assessed on postnatal days 2, 4, 7, 14, and 30.
Compared with the no-exposure group, SSRI-exposed infants had lower quality…