It can — if men who have sex with men know precisely when they will have intercourse.
Preexposure prophylaxis (PrEP) with oral tenofovir/FTC is effective in preventing HIV infection among men who have sex with men (MSM), but adherence to the daily regimen can be challenging and may affect the degree of risk reduction (NEJM JW AIDS Clin Care Jan 2011 and N Engl J Med 2010; 363:2587). How well does preexposure prophylaxis work when used only just before and just after sexual intercourse, rather than every day?
To find out, investigators randomized 400 HIV-uninfected MSM (median age, about 34) in France and Canada to receive either tenofovir/FTC (loading dose of 2 pills to be taken 2 to 24 hours before sex, 1 pill 24 hours after the first dose, and a fourth pill 24 hours later) or matching placebo. Most participants were not in …
Reviewing Author
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)