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We are pleased to bring you our list of the Top 10 stories covered by NEJM Journal Watch Women's Health in 2015. Stories with the potential to change day-to-day practice include the availability of a new 9-valent vaccine against human papillomavirus (HPV), the finding that the etonogestrel implant and levonorgestrel intrauterine device (IUD) provide effective contraception far longer than originally indicated, and the discovery that levonorgestrel emergency contraception has minimal efficacy in women weighing >75 kg (165 lbs). Issues in the obstetric arena include the emerging use of cell-free DNA to screen for fetal trisomies, various strategies to lower cesarean delivery rates, and best practices for skin closure after cesarean delivery. …