Metformin Use in Overweight/Obese Adolescents with Type 1 Diabetes

In a 6-month trial, the addition of metformin to standard insulin regimens was not associated with lower HbA_1C levels.

A growing proportion of adolescents with type 1 diabetes mellitus (T1DM) are overweight or obese. Metformin appears to have some benefit in overweight/obese adults with T1DM, but data for adolescents are lacking.

Investigators from 26 sites randomized 140 adolescents (mean age, 15.3 years; age range, 12–19.6 years; 66% female; 74% white) with presumed autoimmune T1DM (age <10 years at diagnosis or presence of diabetes-related autoantibodies) to receive 2000 mg metformin daily or placebo. Insulin doses were adjusted according to the clinical judgment of treating clinicians. The primary study outcome was change in HbA_1C levels (8.8% at baseline in both groups).

At 13 weeks, the metformin group had a 0.2% decrease in HbA_1C compared with a 0.1% i…

Reviewing Author

Alain Joffe, MD, MPH, FAAP

Disclosures

Nothing to disclose

Alain Joffe, MD, MPH, FAAP

Disclosures

Nothing to disclose

Metformin Use in Overweight/Obese Adolescents with Type 1 Diabetes

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Reviewing Author