Risk Loci for Atopic Dermatitis

Twenty-seven loci were associated with AD, including 16 previously known and 11 new loci.

Although the appearance of atopic dermatitis (AD) is strongly influenced by environmental factors, predisposition to its development is determined by certain genes. For example, mutations of the FLG gene that encodes filaggrin result in deficiency of barrier function of the stratum corneum. Other susceptibility genes are being discovered via various strategies and models, including genome-wide association studies (GWASs) that compare genomes of affected and unaffected persons.

Investigators used 26 GWASs to perform a meta-analysis of more than 15 million genetic variants in 21,399 patients with AD and 93,464 controls. Twenty-seven loci were associated with AD, including 16 that were previously known and 11 new loci. Of these 27, 21 have been…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)