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Patients with debilitating Crohn disease who have exhausted medical and surgical options have been treated with autologous hematopoietic stem cell transplantation.
In the current report, researchers described aspects of stem cell transplantation in 26 candidates with Crohn disease at a single center. They identified some protocol steps that seem uniquely important with regard to stem cell transplantation in patients with Crohn disease as opposed to other autoimmune disorders. These include the following:
During the mobilization phase, bacteremia in Crohn disease caused by gut bacteria could be reduced by switching from a low-microbial diet plus piperacillin–tazobactam to doripenem plus n.p.o. and parenteral nutrition.
Complications such as ste…