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In 2009, the U.S. Preventive Services Task Force (USPSTF) recommended that biennial mammography screening in average-risk women begin at age 50 (NEJM JW Womens Health Dec 2009 and Ann Intern Med 2009; 151:716). Now, based on reviews and modelling studies, the USPSTF has updated and clarified this guidance, with particular attention to individualized screening for women in their 40s, tomosynthesis, and supplemental evaluation for women with radiologically dense breasts.
The new guidance does not apply to women at substantially higher-than-average risk for breast cancer, including those with prior breast cancer or biopsy-confirmed high-risk lesions (e.g., atypical hyperplasia), certain genetic conditions (e.g., BRCA1 or BRCA2 mutation), or his…