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Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection. Obtaining fresh stool from volunteer donors is expensive and inconvenient because it requires screening donors for a number of infections.
In the current randomized, controlled noninferiority trial, investigators assessed clinical resolution in 219 patients with recurrent or refractory C. difficile infection who were administered either frozen or fresh (within 24 hours of being passed) feces by rectal enema. Donors received recommended health screening.
Clinical resolution (resolution of diarrhea at 13 weeks after undergoing 1–2 FMTs) was 83.5% with frozen and 85.1% with fresh feces in the per-protocol analysis and 75.0% with frozen…