Not All Psychosis High-Risk States Are the Same

Pay close attention to patients with mild intermittent psychotic symptoms and declining function.

The possibility that early intervention can attenuate progression of high-risk states to psychosis (NEJM JW Psychiatry May 2012 and Am J Psychiatry 2012; 169:374) has increased the importance of determining what is actually a high-risk state. To address this issue, researchers performed a meta-analysis of 33 studies involving 4227 people thought to be at risk for psychosis and having at least one follow-up assessment.

Patients were felt to be at ultra-high risk for psychosis if they had:

Attenuated psychotic symptoms (APS): mild positive symptoms without psychotic conviction, in some cases with a decline in functioning (85%),
Brief limited intermittent psychotic symptoms (BLIPS): transient, nonserious psychotic symptoms lasting part of the day…

Reviewing Author

Steven Dubovsky, MD

Disclosures

Grant/Research SupportTower Foundation; Patrick Lee Foundation; Boehringer Ingelheim; Intra-Cellular Therapies; Janssen; Biogen; Allergan

Editorial BoardsMind and Brain; Bulletin of the Menninger Clinic; Current Psychiatry; Journal of Psychosomatic Research

Steven Dubovsky, MD

Disclosures

Grant/Research SupportTower Foundation; Patrick Lee Foundation; Boehringer Ingelheim; Intra-Cellular Therapies; Janssen; Biogen; Allergan

Editorial BoardsMind and Brain; Bulletin of the Menninger Clinic; Current Psychiatry; Journal of Psychosomatic Research

Not All Psychosis High-Risk States Are the Same

Topics

Reviewing Author