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Because loop electrosurgical excision procedures (LEEP) for cervical intraepithelial neoplasia (CIN) can have adverse effects, therapeutic alternatives are important. Investigators in Austria conducted a retrospective cohort study of 241 women (median age, 31) with CIN 1–3 who received a single administration of 85% trichloroacetic acid (TCA) performed by one clinician at a colposcopy clinic. TCA, which causes protein denaturation and cell death, was applied to the ectocervix with a cotton swab and to the endocervical canal with the wooden end of the swab. Cervical cytology, type-specific human papillomavirus testing, and colposcopy were performed 8 weeks later.
Among women with biopsy results, no evidence of CIN was seen in 84% of those wit…