Loading...
Cannabinoids, especially tetrahydrocannabinol (THC) and cannabidiol (CBD), are receiving increasing interest for their anticonvulsant effect. Some U.S. states permit marijuana use for epilepsy, despite the lack of robust evidence. CBD has shown interesting results in animals and in small clinical studies on epilepsy, and also has myorelaxant properties. To test CBD as an add-on drug, 214 patients aged 1 to 30 years who had intractable, childhood-onset epilepsy and ≥4 motor seizures monthly received a 99% pure sesame-oil CBD extract (titrated from 2–5 mg/kg to 25 mg/kg daily [50 mg/kg for 23 participants]). About 40% had Lennox-Gastaut or Dravet syndrome. The study was partially manufacturer-funded.
In the 137 intention-to-treat participants,…