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Very few clinical trials focus on patients in their eighties and nineties even though they constitute a growing percentage of people hospitalized with cardiovascular disease. In an open-label trial, investigators from Norway randomized 457 patients (mean age, 85; range 80–94) with non–ST-segment-elevation myocardial infarction to an early invasive strategy (angiography) or conservative therapy. Regarding revascularizations in the invasive group, 47% received percutaneous coronary interventions and 3% received coronary artery bypass grafting procedures. Median follow-up was 1.5 years.
Incidence of the primary endpoint — a composite of myocardial infarction, need for urgent revascularization, stroke, and death — was significantly lower in the …