Transfusion and Risk for Acute Nonvariceal Upper Gastrointestinal Hemorrhage

In a retrospective study, transfusion of packed red blood cells was associated with poor clinical outcomes while platelet transfusions augmented hemostasis.

The treatment of severe acute nonvariceal upper gastrointestinal bleeding (AUGIB) may involve transfusion of blood products. To determine the associations between transfusions and clinical outcomes, investigators in Denmark reviewed the records of 5107 patients with 5681 admissions requiring endoscopic therapy for AUGIB between 2011 and 2013. The relations between clinical outcomes and transfusion of packed red blood cells (PRBCs), fresh frozen plasma (FFP), and platelets (PLT) were determined.

The number of units of transfused PRBCs was associated with higher risk for re-endoscopy, surgery, and 30-day mortality (odds ratios, 1.08, 1.05, and 1.04, respectively). Transfusion of FFP was associated with higher risk for surgery and death (ORs, 1…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Transfusion and Risk for Acute Nonvariceal Upper Gastrointestinal Hemorrhage

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Reviewing Author