Dupilumab Shows Promise for Managing Nasal Polyposis

Chronic sinusitis can be categorized on the presence or absence of nasal polyps. A 2015 systematic review supported daily use of saline irrigation plus topical intranasal corticosteroids as first-line therapy for all patients with chronic sinusitis, with short courses of systemic corticosteroids or doxycycline or daily leukotriene-antagonist therapy for patients with nasal polyps (JW Gen Med Oct 1 2015 and JAMA 2015; 314:926). Despite maximal medical therapy, many patients still suffer from substantial decreases in quality in life; although sinus surgery is helpful, it often does not provide complete relief, and polyps recur in about half of surgery patients. Because nasal polyposis is an eosinophilic disease associated with TH₂-type cytoki…