Profiling the Gut Microbiome in Juvenile Idiopathic Arthritis

Children with JIA had distinct alterations in the gut microbiome, compared with controls.

The more we learn about the gut microbiome at the phyla and genera level, thanks to advances in microbiology, the clearer it becomes that an altered gut microbiome is implicated in autoimmune and rheumatic diseases. Researchers in Finland analyzed the gut microbiome of children with newly diagnosed juvenile idiopathic arthritis (JIA).

From June 2011 to January 2014, they obtained stool samples from 30 children (aged 1–15 years) with newly diagnosed JIA and from 27 control children who did not have autoimmune diseases. No patients or controls had recently had infections or received antibiotic treatment. Microbiome composition was analyzed with 16S ribosomal RNA hypervariable region V4–V5-based sequence profiling.

The proportion of gut-microbio…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Profiling the Gut Microbiome in Juvenile Idiopathic Arthritis

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Reviewing Author