Examining the Relationship Between Obstructive Sleep Apnea and Reflux

Obesity plays an important role in the association.

Studies suggest a causal association between obstructive sleep apnea (OSA) and gastroesophageal reflux (GER). The pathophysiologic hypothesis is that negative intrathoracic pressures generated during OSA events precipitate reflux. Studies have also shown that both OSA and GER symptoms improve with nasal continuous positive airway pressure (CPAP). These authors examined the role of obesity in the association between OSA and GER.

Researchers prospectively compared the frequency of reflux events, lower esophageal sphincter (LES) function, and esophageal motility in three groups: nonobese adults with moderate-to-severe OSA (17), obese adults with moderate-to-severe OSA (9), and obese controls without OSA (20). All participants underwent esophage…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors