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Verrucous carcinoma, a variant of squamous cell carcinoma, is slow-growing but potentially locally destructive. Although most commonly found in the oropharynx, the ano-genital area is also frequently affected. Its relationship with human papilloma virus (HPV) is controversial.
A retrospective review at a tertiary healthcare center detected six stage I cases of vulvar verrucous carcinoma (vVC). Patients (mean age, 55) complained of exophytic masses on the right labia minora or majora associated with pain and pruritus. HPV testing performed in two cases was negative. Surgical excision with negative margins was the treatment of choice. Over a mean follow-up of ~18 months, no recurrence occurred. Of 61 cases reported in the same period in the me…