Increased Risk for Cardiovascular Adverse Events in Patients with Hidradenitis Suppurativa

HS is a chronic inflammatory process, and patients also have increased frequency of obesity and diabetes, features favoring enhanced cardiovascular risk.

Hidradenitis suppurativa (HS), an inflammatory skin disorder with recurrent, draining abscesses occurring in the axillary, genital, and inframammary skin, is associated with increased expression of such inflammatory cytokines as interleukin (IL)-1α, tumor necrosis factor α, IL-10, and IL-17. Other inflammatory diseases (e.g., rheumatoid arthritis, psoriasis) are associated with increased risk for major adverse cardiovascular events and increased mortality. To determine whether cardiovascular morbidity and mortality are greater in people with HS, the authors compared 6000 HS patients without prior cardiovascular disease from the Danish National Patient Registry and age- and sex-matched controls for a mean of 7.1 years.

Incidences of myocardia…

Reviewing Author

Craig A. Elmets, MD

Disclosures

Consultant / Advisory board Astellas Pharmaceuticals

EquityVaxin

Grant / Research support NIH; NIH/NCI; Veteran’s Administration; Ferndale Laboratories; Kyowa Hakko Kirin Pharma, Inc.

Editorial boards Cancer Prevention Research; Photodermatology, Photoimmunology, & Photomedicine; UpToDate; eMedicine; Journal of Dermatological Sciences; JAMA Dermatology

Leadership positions in professional societies American Academy of Dermatology (Vice Chair, Committee on Science and Research); Photomedicine Society (Board of Directors)