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Because people with attention-deficit/hyperactivity disorder (ADHD) have high rates of mood disorders, researchers examined the effect of ADHD treatment on depressive disorders.
The study used diagnostic and prescription data from Swedish registries on 38,752 ADHD patients born between 1960 and 1998 (male, 68%; aged 8–15 years, 45%). ADHD prescriptions were tracked from 2006 to 2008.
On the primary outcome of new onset of depression during 2009, depression occurred at a 43% lower rate in patients receiving ADHD treatment in 2006 than in untreated patients. Depression rates were similar in those with and without prior histories of depression. Within-participant analyses of depression during 2006 through 2009 that controlled for antidepressant …