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Some patients who are awaiting kidney transplantation have anti-human leukocyte antigen (HLA) antibodies. Although such patients can undergo desensitization and transplantation with kidneys from incompatible live donors, these transplants have poorer outcomes than those from compatible live donors. Nevertheless, a transplant from an incompatible live donor might be preferable to remaining on a waiting list. In this multicenter U.S. study, researchers examined outcomes among 1025 adults who underwent transplantation with kidneys from HLA-incompatible live donors. Controls were patients who were on a waiting list for compatible deceased donors but were otherwise similar to the transplanted patients.
One-year, 5-year, and 8-year survival rates …