Caffeine Is Associated with Reduced Risk for Acute Kidney Injury in Premature Newborns

Caffeine exposure reduced risk by 70% to 80%.

Acute kidney injury (AKI) is common in very-low-birth-weight (VLBW) newborns. Researchers retrospectively examined the effect of caffeine exposure on AKI (defined as an increase in serum creatinine by ≥0.3 mg/dL within 48 hours or by 150% to <200% from previous trough) in 140 consecutive VLBW neonates (birth weight <1500 g). Caffeine was administered during the first week after birth in 35 infants at the discretion of the neonatologist.

Among the 101 neonates (72%) who received caffeine, 18 (18%) developed AKI within 10 days. Among the 39 infants who did not receive caffeine, 17 (44%) developed AKI. The reduction in risk associated with caffeine was significant for stage 1 (less severe) AKI but not for stage 2 or 3 AKI. In logistic regressio…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Caffeine Is Associated with Reduced Risk for Acute Kidney Injury in Premature Newborns

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Reviewing Author