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Staphylococcus aureus bloodstream infection is associated with considerable morbidity and a 30-day mortality of about 20% to 30%. However, little is known about the long-term prognosis of S. aureus bacteremia (SAB), as most studies followed patients for 90 days or less. Researchers in Israel now report results of a retrospective study involving 1692 patients with a first SAB episode (at a mean age of 70; 60% male) treated at their institution between January 1999 and December 2010.
Thirty-day, 1-year, and 5-year mortality rates were 40%, 62%, and 72%, respectively. On multivariate analysis, variables significantly associated with mortality were age, female sex, pneumonia or unknown source of infection, dementia, Charlson score, shock at onse…