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Helicobacter pylori infection has been inversely associated with allergic diseases, including asthma and atopic dermatitis. Now, researchers have assessed its relationship with eosinophilic esophagitis (EoE), a chronic allergic condition mediated by immune antigens.
Investigators compared the prevalence of H. pylori between 58 patients (81% men) with histologically documented EoE and 116 age- and sex-matched controls. All participants were tested for immunoglobulin G antibodies to H. pylori. Results were as follows:
Among patients with EoE, three (5.2%) were seropositive for H. pylori, compared with 37.9% among controls (P<0.0001), and another five patients (8.6%) with negative serology results had a history of prior H. pylori eradication the…