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Women's clot risk increases during pregnancy and escalates further during the postpartum period. Antithrombin deficiency (AD) raises risk for clot, although heterozygous carriers of AD often remain asymptomatic. To clarify whether asymptomatic women with inherited AD may benefit from peripartum thromboprophylaxis, researchers conducted a systematic review of studies published between 1966 and 2012.
Three retrospective cohort studies involved 42 women with previously asymptomatic AD who carried 112 pregnancies, of which 13 (12%) were complicated by venous thrombosis. Pooled analysis of four case-control studies found the odds of pregnancy-related thrombosis to be more than six times higher among women with previously asymptomatic AD than amon…