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Antibiotic-resistant gram-negative organisms are increasingly seen in hospitalized patients. Community-acquired antibiotic resistance has been noted for S. aureus but less so for gram-negative organisms. Outpatient treatment of children with urinary tract infection (UTI) relies on oral antibiotics with narrow activity against gram-negative organisms and has been relatively unchanged for the last several decades. Now, investigators have assessed the global prevalence of antibiotic resistance among pediatric UTIs treated in the community setting.
In 58 observational studies from 26 countries, both developed (belonging to the Organisation for Economic Co-operation and Development, or OECD) and developing (non-OECD), researchers assessed resista…