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Promptly and accurately estimating the clinical probability of acute coronary syndrome (ACS) allows better triage and management of high-risk patients and prevents unnecessary observation and work-up of lower-risk patients. In this meta-analysis, researchers evaluated 58 prospective emergency department studies that involved diagnostic test accuracy among patients with suspected ACS but no initial ST-segment elevation on electrocardiograms (ECGs).
Clinical findings that portended excess ACS risk included hypotension (systolic blood pressure, <100 mm Hg; positive likelihood ratio, 3.9), abnormal prior stress test (LR, 3.1), peripheral artery disease (LR, 2.7), radiation to both arms (LR, 2.6), and pain similar to prior ischemia (LR, 2.2). ECG…