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A metabolome is the collection of all the metabolites in a biological system. Dietary changes such as lowering levels of fermentable oligosaccharides, disaccharides and monosaccharides, and polyols (FODMAPs) can improve symptoms of irritable bowel syndrome (IBS) and are known to affect the types of bacteria in the bowel. To determine the possible systemic effect of FODMAPs, researchers evaluated their effect on metabolomes such as urinary metabolomes.
Forty patients with IBS were randomized to a low-FODMAP or high-FODMAP diet for 3 weeks. In the low-FODMAP group, the IBS symptom score improved by 28%, including a 52% improvement in abdominal pain, whereas the IBS symptom score increased in the high-FODMAP group. The low-FODMAP diet resulted …