Are PPIs, NSAIDs, and SSRIs Associated with Microscopic Colitis?

Population-based studies suggest an association between microscopic colitis and a variety of medications, including proton-pump inhibitors (PPIs), nonsteroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), and statins. To further evaluate these potential relationships, investigators compared drug use in 1211 adults with microscopic colitis (including collagenous colitis and lymphocytic colitis) and 6041 age- and sex-matched controls identified from a U.K. research database.

Current use of NSAIDs, PPIs, or SSRIs (adjusted odds ratios, 1.9, 3.4, and 2.0, respectively) but not statins was associated with elevated risk for microscopic colitis compared with never use. Recent use of NSAIDs or PPIs was also asso…